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dc.contributor.authorCheruiyot EKen
dc.contributor.authorBett RCen
dc.contributor.authorAmimo JOen
dc.contributor.authorZhang Yen
dc.contributor.authorMrode Ren
dc.contributor.authorMujibi FDNen
dc.date.accessioned2019-02-06T10:13:04Z
dc.date.available2019-02-06T10:13:04Z
dc.date.issued2018
dc.identifier.citation9:607en
dc.identifier.urihttps://doi.org/10.3389/fgene.2018.00607
dc.identifier.urihttp://hdl.handle.net/11262/11587
dc.description.abstractMultiple studies have investigated selection signatures in domestic cattle and other species. However, there is a dearth of information about the response to selection in genomes of highly admixed crossbred cattle in relation to production and adaptation to tropical environments. In this study, we evaluated 839 admixed crossbred cows sampled from two major dairy regions in Tanzania namely Rungwe and Lushoto districts, in order to understand their genetic architecture and detect genomic regions showing preferential selection. Animals were genotyped at 150,000 SNP loci using the Geneseek Genomic Profiler (GGP) High Density (HD) SNP array. Population structure analysis showed a large within-population genetic diversity in the study animals with a high degree of variation in admixture ranging between 7 and 100% taurine genes (dairyness) of mostly Holstein and Friesian ancestry. We explored evidence of selection signatures using three statistical methods (iHS, XP-EHH, and pcadapt). Selection signature analysis identified 108 candidate selection regions in the study population. Annotation of these regions yielded interesting genes potentially under strong positive selection including ABCG2, ABCC2, XKR4, LYN, TGS1, TOX, HERC6, KIT, PLAG1, CHCHD7, NCAPG, and LCORL that are involved in multiple biological pathways underlying production and adaptation processes. Several candidate selection regions showed an excess of African taurine ancestral allele dosage. Our results provide further useful insight into potential selective sweeps in the genome of admixed cattle with possible adaptive and productive importance. Further investigations will be necessary to better characterize these candidate regions with respect to their functional significance to tropical adaptations for dairy cattle.en
dc.language.isoenen
dc.relation.isformatof15024en
dc.relation.ispartofFrontiers in Geneticsen
dc.subjectSelection signaturesen
dc.subjectCrossbred cattleen
dc.subjectAdmixtureen
dc.subjectiHSen
dc.subjectXP-EHHen
dc.subjectpcadapten
dc.subjectSNPen
dc.titleSignatures of selection in admixed dairy cattle in Tanzaniaen
dc.typeArticleen
dc.description.versionVersion of Record
rioxxterms.publicationdate2018-12-19
rioxxterms.typeJournal Article/Reviewen
dcterms.dateAccepted2018-11-19
refterms.accessExceptionNAen
refterms.dateDeposit2019-02-06
refterms.depositExceptionpublishedGoldOAen
refterms.depositExceptionExplanationGoldOAen
refterms.panelUnspecifieden
refterms.technicalExceptionNAen
refterms.versionVoRen


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