Show simple item record

dc.contributor.authorMichailidou Sen
dc.contributor.authorTsangaris Gen
dc.contributor.authorFthenakis GCen
dc.contributor.authorTzora Aen
dc.contributor.authorSkoufos Ien
dc.contributor.authorKarkabounas SCen
dc.contributor.authorBanos Gen
dc.contributor.authorArgiriou Aen
dc.contributor.authorArsenos Gen
dc.date.accessioned2018-03-05T16:53:08Z
dc.date.available2018-03-05T16:53:08Z
dc.date.issued2018
dc.identifier.citation293:3
dc.identifier.issn1617-4615
dc.identifier.urihttps://doi.org/10.1007/s00438-018-1421-x
dc.identifier.urihttp://hdl.handle.net/11262/11412
dc.description.abstractIn the present study, genome-wide genotyping was applied to characterize the genetic diversity and population structure of three autochthonous Greek breeds: Boutsko, Karagouniko and Chios. Dairy sheep are among the most significant livestock species in Greece numbering approximately 9 million animals which are characterized by large phenotypic variation and reared under various farming systems. A total of 96 animals were genotyped with the Illumina’s OvineSNP50K microarray beadchip, to study the population structure of the breeds and develop a specialized panel of single-nucleotide polymorphisms (SNPs), which could distinguish one breed from the others. Quality control on the dataset resulted in 46,125 SNPs, which were used to evaluate the genetic structure of the breeds. Population structure was assessed through principal component analysis (PCA) and admixture analysis, whereas inbreeding was estimated based on runs of homozygosity (ROHs) coefficients, genomic relationship matrix inbreeding coefficients (FGRM) and patterns of linkage disequilibrium (LD). Associations between SNPs and breeds were analyzed with different inheritance models, to identify SNPs that distinguish among the breeds. Results showed high levels of genetic heterogeneity in the three breeds. Genetic distances among breeds were modest, despite their different ancestries. Chios and Karagouniko breeds were more genetically related to each other compared to Boutsko. Analysis revealed 3802 candidate SNPs that can be used to identify two-breed crosses and purebred animals. The present study provides, for the first time, data on the genetic background of three Greek indigenous dairy sheep breeds as well as a specialized marker panel that can be applied for traceability purposes as well as targeted genetic improvement schemes and conservation programs.en
dc.description.sponsorshipScottish Government RESAS Strategic Research Programme (RD2.3.2; SD2)en
dc.language.isoenen
dc.relation.isformatof14788en
dc.relation.ispartofMolecular Genetics and Genomicsen
dc.rightsCopyright © Springer-Verlag GmbH Germany, part of Springer Nature 2018. This is the accepted manuscript of this paper. The final publication is available at Springer via https://doi.org/10.1007/s00438-018-1421-x.
dc.subjectGenetic diversityen
dc.subjectPopulation structureen
dc.subjectOvineSNP50K beadchipen
dc.subjectOvis ariesen
dc.subjectBreed identificationen
dc.subjectConservationen
dc.subjectBreeding programsen
dc.titleGenomic diversity and population structure of three autochthonous Greek sheep breeds assessed with genome-wide DNA arraysen
dc.typeArticleen
dc.description.versionAccepted manuscript
dc.extent.pageNumbers753-768
rioxxterms.publicationdate2018-01-25
rioxxterms.typeJournal Article/Reviewen
dcterms.dateAccepted2018-01-17
refterms.accessExceptionNAen
refterms.dateDeposit2018-03-05
refterms.dateEmbargoEnd2019-01-25
refterms.dateFreeToDownload2019-01-25
refterms.dateFreeToRead2019-01-25
refterms.dateToSearch2019-01-25
refterms.depositExceptionNAen
refterms.panelUnspecifieden
refterms.technicalExceptionNAen
refterms.versionAMen


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record