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dc.contributor.authorKhattak FMen
dc.contributor.authorPaschalis Ven
dc.contributor.authorGreen Men
dc.contributor.authorHoudijk JGMen
dc.contributor.authorSoultanas Pen
dc.contributor.authorMahdavi Jen
dc.date.accessioned2017-11-29T12:29:52Z
dc.date.available2017-11-29T12:29:52Z
dc.date.issued2017
dc.identifier.issn0032-5791
dc.identifier.urihttp://hdl.handle.net/11262/11354
dc.descriptionAccepted for publicationen
dc.description.abstractReducing Campylobacter spp. carriage in poultry is challenging, but essential to control this major cause of human bacterial gastroenteritis worldwide. Although much is known about the mechanisms and route of Campylobacter spp. colonization in poultry the literature is scarce on antibiotic-free solutions to combat Campylobacter spp. colonization in poultry. In vitro and in vivo studies were conducted to investigate the role of TYPLEX® Chelate (ferric tyrosine), a novel feed additive, in inhibiting Campylobacter jejuni (C. jejuni) biofilm formation and reducing C. jejuni and Escherichia coli (E. coli) colonization in broiler chickens at market age. In an in vitro study, the inhibitory effect on C. jejuni biofilm formation using a plastic bead assay was investigated. The results demonstrated that TYPLEX® Chelate significantly reduces biofilm formation. In an in vivo study, 800 broilers (one-day old) were randomly allocated to 4 dietary treatments in a randomised block design, each having 10 replicate pens with 20 birds per pen. At day 21, all birds were challenged with C. jejuni via seeded litter. At day 42, caecal samples were collected and tested for volatile fatty acid (VFA) concentrations, C. jejuni and E. coli counts. The results showed that TYPLEX® Chelate reduced the carriage of C. jejuni and E. coli in poultry by 2 and 1 log10 per gram caecal sample, respectively, and increased caecal VFA concentrations. These findings support TYPLEX® Chelate as a novel non-antibiotic feed additive that may help produce poultry with a lower public health risk of Campylobacteriosis.en
dc.language.isoenen
dc.relation.isformatof14734en
dc.relation.ispartofPoultry Scienceen
dc.subjectCampylobacteren
dc.subjectBiofilmen
dc.subjectVolatile fatty aciden
dc.subjectFeed additiveen
dc.subjectFood safetyen
dc.titleTYPLEX® Chelate inhibits Campylobacter jejuni biofilm formation and caecal colonization in broiler chickensen
dc.typeArticleen
dc.description.versionAccepted manuscript
rioxxterms.typeJournal Article/Reviewen
dcterms.dateAccepted2017-11-26
refterms.accessExceptionNAen
refterms.dateDeposit2017-11-29
refterms.depositExceptionNAen
refterms.panelUnspecifieden
refterms.technicalExceptionNAen
refterms.versionAMen


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