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dc.contributor.authorSantos Men
dc.contributor.authorDias-Pereira Pen
dc.contributor.authorCorreia-Gomes Cen
dc.contributor.authorMarcos Ren
dc.contributor.authorde Matos Aen
dc.contributor.authorRocha Een
dc.contributor.authorLopes Cen
dc.date.accessioned2017-06-14T10:14:00Z
dc.date.available2017-06-14T10:14:00Z
dc.date.issued2017
dc.identifier.issn0903-4641
dc.identifier.urihttps://doi.org/10.1111/apm.12717
dc.identifier.urihttp://hdl.handle.net/11262/11250
dc.description.abstractGrading of canine mammary carcinomas (CMC) is associated to subjective assessments made by the pathologists. Due to its unbiased nature, stereology can be used to objectively quantify morphological parameters associated with grading and malignancy. However, the use of stereology in CMC has not been fully disclosed. The nuclear numerical density [NV (nuclei, tumor)] is a cellularity-associated parameter that can be estimated by the optical disector. Herein, it was estimated in 44 CMC and its association with clinicopathologic factors – such as tumor size, histological subtype and grade, vascular/lymph node invasion, nuclear pleomorphism, and survival – was evaluated. Considering all the cases, the mean NV (nuclei, tumor) was 1.6 × 106 ± 0.5 × 106 nuclei/mm3. Lower values were attained in complex carcinomas, comparing to simple carcinomas, in tumors smaller than 5 cm, with low mitotic activity and in those with high nuclear pleomorphism. No statistically significant association with grade or vascular/lymph node invasion was observed, but tumors with disease progression had lower nuclear densities. The NV (nuclei, tumor) and the correlated parameters mirror to some extension those in human breast cancer, suggesting an interesting interspecies agreement. This first estimation of the nuclear numerical density in CMC highlights the feasibility of the optical disector and their utility for objective morphological assessments in CMC. The association between nuclear numerical density and disease progression warrants future studies.en
dc.language.isoenen
dc.relation.isformatof14613en
dc.relation.ispartofActa Pathologica, Microbiologica et Immunologica Scandinavica (APMIS)en
dc.rightsCopyright © 2017 APMIS. Published by John Wiley & Sons Ltd. This is the accepted version of the above article, which has been published in final form at: https://doi.org/10.1111/apm.12717
dc.subjectCanine mammary tumorsen
dc.subjectDisectoren
dc.subjectGradeen
dc.subjectPrognosisen
dc.subjectStereologyen
dc.titleUse of the optical disector in canine mammary simple and complex carcinomasen
dc.typeArticleen
dc.description.versionAccepted manuscript
rioxxterms.publicationdate2017-06-06
rioxxterms.typeJournal Article/Reviewen
dcterms.dateAccepted2017-04-07
refterms.accessExceptionNAen
refterms.dateDeposit2017-06-14
refterms.dateEmbargoEnd2018-06-06
refterms.dateFreeToDownload2018-06-06
refterms.dateFreeToRead2018-06-06
refterms.dateToSearch2018-06-06
refterms.depositExceptionNAen
refterms.panelUnspecifieden
refterms.technicalExceptionNAen
refterms.versionAMen


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