Anthelmintic Ethiopian medicinal plants for small ruminants: in vitro and in vivo studies
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BACKGROUND: Medicinal plants play an important role for parasite control in developing countries. However, scientific evidence on plant efficacy and potential side effects is scarce. Here, we present in vitro and in vivo evidence of anthelmintic properties of Ethiopian medicinal plants. METHODS: Thirty medicinal plants, selected from an ethno-botanical survey, were dried and extracted by three solvents (methanol, 70%-methanol and water). Teladorsagia circumcincta L3 motility was recorded for 24 h prior and 24 h after addition of the 90 resulting extracts through an automated larval motility assay that quantifies anthelmintic activity. Faecal egg counts (FEC) and feed intake were measured in sheep, sham-infected or infected with 15,000 L3 T. circumcincta, and drenched with water concoctions of two plants that showed strong in vitro efficacy. RESULTS: Twenty-three of 25 plants, routinely used by traditional healers against endo-parasites, including Albenzia anthelmintica, showed 100% larval motility inhibition for at least one of the solvents tested. Furthermore, 3 of 5 plants routinely used against ecto-parasites, including Dodonea angustifolia, also showed strong in vitro anthelmintic activity. Drenching with A. anthelmintica and D. angustifolia concoctions reduced FEC by 51 and 57%, respectively (P<0.05). Feed intake was temporarily reduced for A. anthelmintica only. CONCLUSIONS: The study shows that scientific validation of ethnoveterinary knowledge has great potential to assist informing plant-based parasite control strategies.
Other Titles/Title of Conference
13th ICOPA: International Conference of Parasitology, Mexico City, Mexico
International Congress of Parasitology